Alpha-lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. Alpha-lipoic acid acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. It may well be the perfect antioxidant. Alpha-lipoic acid has researched for use in the treatment of HIV and diabetes Because it dissolves in both water and fat, this so-called "universal antioxidant" is able to scavenge more wayward free-radical cells than most antioxidants, the majority of which tend to dissolve in either fat or water but not both. Alpha-lipoic acid can reach tissues composed mainly of fat, such as the nervous system, as well as those made mainly of water, such as the heart. The body makes small amounts of alpha lipoic acid.5740 Руб.
Recent advances in the neurobiology of Aging explains the role of nutritional supplements in the modulation of brain physiology,morphology, and vascular development and suggested new ways of drug administration in disease and health in particular to the aging society. Nutritional supplements alters with the signalling of neurotransmitters in the central nervous system in particular, the Cholinergic and the dopaminergic pathways which primarily controls voluntary and involuntary physiological actions.In this piece of work,I did evaluate the role of Alpha lipoic acid (thioctic acid), Posiphen supplementation in a model of cerebrovascular injury administered in the aged rats and transgenic mice models. The bioavailability of tizanidine(Sirdalaud) was used as a good model in evaluating intra nasal route of administration as an alternative route especially in the aging group with swallowing difficulties.6313 Руб.