Alpha-lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. Alpha-lipoic acid acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. It may well be the perfect antioxidant. Alpha-lipoic acid has researched for use in the treatment of HIV and diabetes Because it dissolves in both water and fat, this so-called "universal antioxidant" is able to scavenge more wayward free-radical cells than most antioxidants, the majority of which tend to dissolve in either fat or water but not both. Alpha-lipoic acid can reach tissues composed mainly of fat, such as the nervous system, as well as those made mainly of water, such as the heart. The body makes small amounts of alpha lipoic acid.5415 Руб.
Hepatic encephalopathy(HE)is a severe complication of cirrhosis that is related to the effect of excess ammonia.The present study was constructed to investigate the potent role of L-carnitine, ?-lipoic acid either individually or in combination in management of hepatic encephalopathy in adult male rats. The aim of this study was extended to elucidate the most effective therapy against experimental hepatic encephalopathy. The present results revealed that the treatment with lactulose, L-carnitine, ?-lipoic acid or a combined dose of L-carnitine and ?-lipoic acid resulted in pronounced improvement in the liver functions accompanied with significant modulation in hepatic and brain oxidant/antioxidant homeostasis in addition to marked suppression in the inflammatory mediators. Also, the selected treatments could restore the structural organization of liver and brain. In conclusion, the present study provided clear evidences for the effectiveness of L-carnitine, ?-lipoic acid or their...5969 Руб.
Recent advances in the neurobiology of Aging explains the role of nutritional supplements in the modulation of brain physiology,morphology, and vascular development and suggested new ways of drug administration in disease and health in particular to the aging society. Nutritional supplements alters with the signalling of neurotransmitters in the central nervous system in particular, the Cholinergic and the dopaminergic pathways which primarily controls voluntary and involuntary physiological actions.In this piece of work,I did evaluate the role of Alpha lipoic acid (thioctic acid), Posiphen supplementation in a model of cerebrovascular injury administered in the aged rats and transgenic mice models. The bioavailability of tizanidine(Sirdalaud) was used as a good model in evaluating intra nasal route of administration as an alternative route especially in the aging group with swallowing difficulties.5956 Руб.
A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.5415 Руб.
Chicken is a very popular food in Pakistan as well as throughout the world because it is delicious, nutritious and can be prepared a multitude of ways.Now a days the link between diet and health has become pivotal because of the prevalence of diet related diseases like obesity, diabetes, hypertension and cardiovascular diseases.so people are now choosy in their demand of meat and meat products due to health related issues.This study was intended to produce the healthy and antioxidant enriched broiler meat and meat products.Alpha lipoic acid(ALA) and Alpha tocopherol acetate(ATA) enriched diet was supplemented to the birds through feed for a time period of 42 days.After slaughtering the fresh meat and meat products(Nuggets and Patties) were analyzed for different analysis.The results confirmed the health benefits of healthier and antioxidant enriched broiler meat and meat products.4615 Руб.
A 3x2 factorial experiment was conducted to evaluate the effect of alpha-tochopherol (Vitamin-E) on the growth performance and fillet quality of Pangasius hypophthalmus in monoculture system installed in earthen pond for 125 days feeding period. The triplicate groups containing 15000 fish were fed DL-alpha-tocopheryl acetate (0, 90 and 300 mg/Kg diet).The result revealed that alpha-tocopherol deficient fish exhibited poor growth performance compared to fish fed with alpha-tocopherol supplemented diets. The BWG, SGR, Protein index and percentage weight gain is effected positively by the amount of Vitamin-E supplementation. Alpha-tocopherol has significant effect on the proximate composition of feed. Lipid content, ash and alpha-tocopherol level of fillet quality is positively affected by the amount of DL-alpha-tocopheryl acetate in diet. But moisture content and crude protein contain is not affected positively by Vitamin-E supplementation. The maximum yield is 4218.75±378.94 kg/ha/yr,...4700 Руб.
Poly gamma glutamic acid (PGGA) is a HPA (homo polyamide) occurring naturally. It is made of D and L form of glutamic acid units which are typically connected by the amide linkages between the alpha-amino group and the gamma-carboxyl group as shown in the figure 4.1.Thus, it has resistance against the protein breaking enzymes known as proteases.Lvanovics discovered it as a capsule component of B.A (bacillus anthracis) which was released in the medium provided on aging and autolysis of the cell or during the process of autoclaving (G.Iv anovics et al.,1937) . Sa wamura (S.Sa wamura, 1913) was first to report that ‘Natto’, formed by the fermentation of Soya beans which is a traditional Japanese food is a mixture of poly gamma glutamic acid and fructan.6240 Руб.
The red flour beetle (Tribolium castaneum) is a common pest insect known for attacking and infesting stored flour and grain. Bacillus thuringiensis (B.t) is a Gram positive, soil dwelling bacteria commonly used as a biological alternative to a pesticide. The present project was designed for the study of combined insecticidal effect of B. t along with boric acid, insecticide cypermethrin and the plant leaves powder, that is, Azadirachta indica against the T. castaneum to check the mortality rate of these insects and LC50 was calculated. Bacteria were isolated from rich soil, pulse dust, grain dust and its growth was checked on the T3 media by applying the microbial techniques. The results obtained show synergism when applied in combined concentration of B.t, boric acid, cypermethrin and powder of neem leaves in 1 g of diet. The combined concentration of each gave higher mortality to larvae and the percentage mortality was calculated as 33, 16 and 16% after 24 h, 41, 25 and 16%...4615 Руб.